New Solutions for the Heart - An Update in Advanced Perioperative Protection by Bruno K. Podesser is an excellent compilation of past, present and future science of this very important and fundamental topic for every cardiac surgeon.
The Editors, Dr. Chambers and Podesser have assembled an all star cast of excellent clinicians and scientists, experts in the general fields of basic cardiac research, cardioplegia research and clinical outcomes research. After an initial excellent historical chapter the various authors present much of the basic science of myocyte physiology, myocardial protection, subjects that have not been well understood. These basic concepts have been summarized beautifully in this book for clinicians and basic science investigators alike.
The next section discusses much of what is currently known about the clinical and physiological effect of cardioplegia on the beating and arrested heart, the optimal protection for the transplanted heart, specific recommendations for right heart protection and a variety of modalities to achieve optimal protection in these situations.
Finally, there are several chapters about the potential future of improved protective cardiac strategies during surgery for an increasing number of patients, particularly the elderly, who will require cardiac surgery over the next decades. The authors have done an excellent job in putting together the best of science and clinical practice of a subject which is critical to successful cardiac surgery and which was put into effect only 30 years ago with the institution of hyperkalemic cardioplegia. Cardioplegia has become a scientific and clinical requirement for excellence in heart surgery.
The results in heart surgery are superb today compared with yesterday and a book like this is very important to stimulate even better results as we operate on more and more elderly patients and patients in extreme heart failure. The editors are to be congratulated on a superb job of getting the best and the brightest authors and investigators in the area of myocardial protection and insisting that we not stand on our laurels, but look to even better physiologic and clinical pathologic correlations for the best protection of hearts during open heart surgery.
Contents
Part I Introduction
1 The Changing Population: The Surgeon’s Challenge
Part II Fundamentals
2 Fundamentals of the Past: Cardioplegia: The First Period Revisited
3 Sites of Injury: Myocyte
4 Sites of Injury: The Endothelium
Part III Special Focus
5 Intraoperative Protection of the Myocardium: Effects of Age and Gender
6 Protection of the Right Heart
7 Protection of the Failing Heart
8 Protection During Heart Transplantation
Part IV New Approaches and Technologies
9 The Endothelium As Target for Interventions
10 Vascular Effects of Cardioplegic Arrest and Cardiopulmonary Bypass
11 Oxygen Radical Scavengers
12 New Approaches to Cardioplegia: Alternatives to Hyperkalemia
13 Myocardial Protection via the Coronary Venous Route
14 Donor Heart Preservation by Continuous Perfusion
15 Visualization of Cardioplegia Delivery
Author Index
Subject Index
About the Editors
The Editors, Dr. Chambers and Podesser have assembled an all star cast of excellent clinicians and scientists, experts in the general fields of basic cardiac research, cardioplegia research and clinical outcomes research. After an initial excellent historical chapter the various authors present much of the basic science of myocyte physiology, myocardial protection, subjects that have not been well understood. These basic concepts have been summarized beautifully in this book for clinicians and basic science investigators alike.
The next section discusses much of what is currently known about the clinical and physiological effect of cardioplegia on the beating and arrested heart, the optimal protection for the transplanted heart, specific recommendations for right heart protection and a variety of modalities to achieve optimal protection in these situations.
Finally, there are several chapters about the potential future of improved protective cardiac strategies during surgery for an increasing number of patients, particularly the elderly, who will require cardiac surgery over the next decades. The authors have done an excellent job in putting together the best of science and clinical practice of a subject which is critical to successful cardiac surgery and which was put into effect only 30 years ago with the institution of hyperkalemic cardioplegia. Cardioplegia has become a scientific and clinical requirement for excellence in heart surgery.
The results in heart surgery are superb today compared with yesterday and a book like this is very important to stimulate even better results as we operate on more and more elderly patients and patients in extreme heart failure. The editors are to be congratulated on a superb job of getting the best and the brightest authors and investigators in the area of myocardial protection and insisting that we not stand on our laurels, but look to even better physiologic and clinical pathologic correlations for the best protection of hearts during open heart surgery.
Contents
Part I Introduction
1 The Changing Population: The Surgeon’s Challenge
Part II Fundamentals
2 Fundamentals of the Past: Cardioplegia: The First Period Revisited
3 Sites of Injury: Myocyte
4 Sites of Injury: The Endothelium
Part III Special Focus
5 Intraoperative Protection of the Myocardium: Effects of Age and Gender
6 Protection of the Right Heart
7 Protection of the Failing Heart
8 Protection During Heart Transplantation
Part IV New Approaches and Technologies
9 The Endothelium As Target for Interventions
10 Vascular Effects of Cardioplegic Arrest and Cardiopulmonary Bypass
11 Oxygen Radical Scavengers
12 New Approaches to Cardioplegia: Alternatives to Hyperkalemia
13 Myocardial Protection via the Coronary Venous Route
14 Donor Heart Preservation by Continuous Perfusion
15 Visualization of Cardioplegia Delivery
Author Index
Subject Index
About the Editors